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Third-party-funded project

Title:
-(see german version)

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Mutations which frequently occur in colon cancer affect to main cellular functions: proliferation and cell survival. Unrestricted proliferation of apoptosis-resistant cell populations provides opportunity for the accumulation of further genetic alterations, required for the manifestation of the fully transformed phenotype. C-Raf is an essential component of proliferation and survival control. In the past mutants of C-Raf have been characterized which selectively affect one of these functions and thus should allow to delineate the contribution of specific Raf-dependent pathways to the development of apoptosis deficiency in colon cancer, which also contributes to therapy resistance. This work aims at the development of strategies to reverse apoptosis resistance. Two different approaches will be followed. For one we attempt the conditional ablation of the C-Raf protein and secondly we aim at blocking Raf-dependent signaling pathways buy using dominant negative mutants of C-Raf.

Key words:
    Colon cancer
    apoptosis
    therapy resistance
    C-Raf

Projekt period: from 04.1999 to 03.2002

Funding institution:
Sonstige Stiftung ( Scheel-Stiftung ) ,Granting date: 25.03.1999

Publications: