Third-party-funded project
Title:
Mechanisms of tumor development
Project management at the University of Würzburg:
Participating scientists:
- Dr. rer. nat. Lev Fedorov
,Tel: 0931/ 201-45847,Fax: 0931/ 201-45835,Mail: imsd023@mail.uni-wuerzburg.de
- PD Dr. rer. nat. Eugen Kerkhoff
,Tel: 0931/ 201-45868,Fax: 0931/ 201-45835,Mail: kerkhoff@mail.uni-wuerzburg.de
- Dr. rer. nat. Thomas Twardzik
,Tel: 0931/ 201-45819,Fax: 0931/ 201-45835,Mail: path092@mail.uni-wuerzburg.de
- Dipl. Biol. Oleg Tyrsine
,Tel: 0931/ 201-45847,Fax: 0931/ 201-45835,Mail: tyrsine.oleg@mail.uni-wuerzburg.de
- Dipl. Biol. Fatih Ceteci
,Tel: 0931/ 201-45158,Fax: 0931/ 201-45835,Mail: Fatih-Ceteci@mail.uni-wuerzburg.de
Abstract:
Lung cancer in man is today the leading cause of cancer death in the world. We have used transgenic mice with lung targeted expression of the CRaf kinase to evaluate genes frequently altered in human lung adenocarcinoma for their effect on tumor progression. A remarkable feature of the CRaf-induced lung tumors was the lack of tumor progression as judged from extensive histological examination. In a search for genes that modify tumor development we recently observed that bcl-2 is required for efficient lung tumor development in mice. Elucidation of additional genes that accelerate tumor development are likely to include, besides regulators of cell death, those genes that are involved in maintaining cell-cell contact and dissemination of cells to distant tissue regions.
Key words:
Lung cancer
Raf oncogene
Projekt period:
from 11.2001 to 10.2003
Funding institution:
Sonstige Stiftung ( Scheel-Stiftung ) ,Granting date: 01.11.2001
Publications:
- Kerkhoff, E., Fedorov, L. M., Siefken, R., Walter, A. O., Papadopoulus, T., and Rapp, U. R..
(2000). Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.. (monograph)
- Fedorov, L. M., Papadopoulos, T., Tyrsin, O. Y., Twardzik, T., Götz, R., and Rapp, U. R..
(2002 im Druck). Bcl-2 determines susceptibility to induction of lung cancer by oncogenic CRaf.. (monograph)
- Fedorov, L. M., Papadopoulos, T., Tyrsin, O. Y., Twardzik, T., Götz, R., and Rapp, U. R..
(eingereicht). Loss of p53 in craf induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch.. (monograph)
