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Third-party-funded project

Title:
Analysis of neuromuscular insufficiency in rotator cuff disease.

Project management at the University of Würzburg:

• Prof. Dr med Frank Gohlke

Participating scientists:

• Dr med Dirk Böhm
• Prof Dr med A Marx
• Dr med S Gattenlöhner
• Dr med Ch Schneider
• PD Dr med A Sommer
• Dr med W Kenn
• Prof Dr med E Heppelmann

Abstract:
Molecular genetic markers of denervation (expression of fetal AchR) and immunhistochemical findings are evaluated in biopsies of human rotator cuff and deltoid muscles of patients suffering from subacromial pain. These parameters are correlated to clinical and neurophysiological findings.

Key words:
    Neuromuscular insufficiency
    muscle atrophy
    rotator cuff
    subacromial pain
    fetal acetylcholine receptor

Projekt period: from 05.2001 to 05.2004

Funding institution:
Landeshaushalt Wissenschaftsministerium ( IZKF )

Publications:

• Gattenlöhner S, Vincent A, Schneider Ch, Thamer C, Klein R, Roggendorf W, Gohlke F, Müller-Hermelink HK, Marx A. (2002). Expression of fetal type acetylcholine receptor is restricted to type I muscle fibers in human neuromuscular disorders. Brain 125:1309-1319, (scientific article)
• Gruß J, Gattenlöhner S, Marx A, Gohlke F. (2000). Veränderte Expression fetaler Acetycholinrezeptoren - ein Hinweis für neuromuskuläre Insuffizienz bei Defekten der Rotatorenmanschette. Z Orthop 138 (Suppl.): 126-127, (scientific article)
• Gohlke F, Gruß J, Gattenlöhner S, Marx A. (2000). Changes in m-RNA expression of acetylcholin receptor subunits - an indication for neuromuscular insufficiency in subacromial pain and rotator cuff tears. In Transactions of the 10th conference of the European Orthopaedic Research Society 10: 0-119 . (conference publication)