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Research focus:  

Neurochirurgische Klinik und Poliklinik
Josef-Schneider-Str. 11, 97080 Würzburg
Mail: klinik@nch.uni-wuerzburg.de
Url: http://www.uni-wuerzburg.de

Scientific members:

   Professors:

   Outside lecturer:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
Tumor biology in basic and clinical research
Main topics (in vitro):
Effect of GM-CSF on protease expression tumor cell lines and primary cultures;
Role of reversion inducing cystein rich kinase in human gliomas;
TrkC expression in Oligodendrogliomas;
MMP Expression in C6 rat gliomas;
in vivo:
Test of UPA und Plasmin antagonists WX-UK1 in animal model;
Immunogenic reaction on 6-spheroids in animal model;
Test of antiangiogenetic tissue-factor inhibitors EDB in animal model

Results:
GM-CSF: Finding of upregulation of proteasis uPA, MMP-2 und MMP-9 under GM-CSF by PCR.
Reversion inducing cystein rich kinase: Finding of RECK protein in 3T3 fibroblasts. Downregulation of the protein in human glioma cells.
TrkC: Expression of factors differentiating in human brain tumors.
MMP: Immunohistochemic expression and survey of Gelatinase A und B.
UPA: Expression of uPA und uPAR in C6 Spheroids implanted in rats.
C6-Spheroid Immunreaktion: MRI-survey of tumor progression in immunocompetent and thymectomiced rats.
EDB: Finding of tumorendothel cells with EDB-Receptors.

Rewards and prizes:
The former head of the group, Professor Dr. med. JC Tonn became head of the department of Neurosurgery of the university of munich.
Publications:
Vince GH et al: Medulloblastoma displays distinct regional matrix metalloprotease expression.
J Neurooncol 2001; 53:99-106.
Schweitzer T et al: Extraneural metastases of primary brain tumors.
J Neurooncol 2001; 53:107-114.
Vince GH et al: Heteregeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.
Int J Dev Neurosci 1999; 17: 437-445.

Equipment:
7 Cellbiological- and molecularbiological work benches;
Tumor tissue bank.