Influence of introduction of mycophenolate mofetil and reduction of ciclosporine on renal dysfunction after cardiac transplantation (IMPROVED study)
Project management at the University of Würzburg:
The aim of this prospective controlled multicenter trial was to investigate whether modifi-cation of immunosuppression in heart transpant recipients on “classical” immunosuppressive therapy with ciclosporin + azathioprin + steroids by introduction of mycophe-nolate mofetil and reduction of ciclosporin leads to improvement of renal dysfunction in compensated renal failure. The study demonstrated a highly significant decrease of serum creatinine and increase in creatinine clearance in the intervention group, while these parameters remained unchanged in the control group.
Projekt period: from 09.1999 to 09.2002
Wirtschaftsunternehmen ( Roche Pharma GmbH ) ,Granting date: 01.09.1999