Klinikstrasse 6-8, 97070 Würzburg
Other participating persons and organisations:
Research foci (and basic equipment-based research projects):
1. Function and specifity of human gamma/delta T cells.
2. Immunotherapy of cancer by stimulation of gamma/delta T cells.
3. Role of the oncogen Nup214/CAN in nuclear export.
4. In-vitro manipulation of hematopoetic stem cells.
5. Clinical multicenter-studies (phase I-III) to improve treatment of different malignant diseases.
6. Immunphenotyping of malignant lymphoma by multicolor flow cytometry.
ad 1. Characterization of antigen recognition mechanisms of human gamma/delta T cells. Identification of natural (metabolites of the alternative mevalonate pathway) and synthetic (aminobisphosphonates such as pamidronate) ligands for Vgamma9Vdelta2 T cells (Feurle J et al. J Biol Chem 2002; 277: 148-154; Kunzmann V et al. N Engl J Med 1999; 340: 737-738)
ad 2. Demonstration of a potent anti-tumor activity of human gamma/delta T cells in in-vitro models. (Kunzmann V et al. Blood 2000; 96: 384-392) Establishment of a clinical Phase I/II trial to evaluate the in-vivo anti-tumor activity of gamma/delta T cells in lymphoma/myeloma patients.
ad 3. Demonstration of an association of the mRNA export factor mrnp41 (Rae1p) with the cytoskeleton (microtubules) in certain cell lines (Kraemer D et al. Eur. J. Cell Biol. 80:733- 740; 2001)
ad 4. Demonstration of successful gene transfer in purified human hematopoetic stem cells using electroporation (Weissinger F et al. J Clin Lab Med. in press; 2002)
ad 5. Realization and analysis of 37 clinical phase II-III multicenter and 2 experimental Phase I-II studies for patients with different hematological or solid neoplasms. Demonstration of an improvement compared to standard treatment in some already closed studies (see also project hämaonko-medpoli 07).
ad 6. Improvement of sensitivity and specificity in lymphoma diagnosis by multicolor flow cytometry.