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Research focus:  

Klinik und Poliklinik für Hals-, Nasen- u. Ohrenkranke
Josef-Schneider-Str. 11, 97080 Würzburg
Mail: marianne.schmidt@mail.uni-wuerzburg.de
Url: http://www.hno.uni-wuerzburg.de

Scientific members:

   Scientific assistants:

Research foci (and basic equipment-based research projects):
The hyperthermic inducible promoter of the Hsp-70 gene as well as a synthetic construct, containing enhancer elements of the Egr-1 gene were tested with a reporter gene assay in head and neck squamous carcinoma cell lines. The aim of the experiments was the use of externally switchable gene promoters together with suicide genes for a gene therapy in head and neck cancer.

Results:
The Hsp-70 promoter proved to be more useful for therapeutic aims, since the function of the radiation inducible promoter was quite dependant on the cell type transfected with the reporter gene system.