Klinik und Poliklinik für Hals-, Nasen- u. Ohrenkranke
Josef-Schneider-Str. 11, 97080 Würzburg
Research foci (and basic equipment-based research projects):
Externally inducible gene promoters in head and neck squamous carcinoma cell lines
The hyperthermic inducible promoter of the Hsp-70 gene as well as a synthetic construct, containing enhancer elements of the Egr-1 gene were tested with a reporter gene assay in head and neck squamous carcinoma cell lines. The aim of the experiments was the use of externally switchable gene promoters together with suicide genes for a gene therapy in head and neck cancer. The Hsp-70 promoter proved to be more useful for therapeutic aims.