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Research focus:  

Klinik und Poliklinik für Hals-, Nasen- u. Ohrenkranke
Josef-Schneider-Str. 11, 97080 Würzburg
Mail: k.schwager@mail.uni-wuerzburg.de
Url:

Scientific members:

   Outside lecturer:

Research foci (and basic equipment-based research projects):
Studies in biocompatibility on alloplastic ossicular replacement prostheses. The main interest is in titanium and titanium alloys with different surface modifications and the acceptance in an animal model (rabbit) and the adsorption of proteins towards the extracellular matrix. In addition histological studies are performed in explanted ossicular replacement prostheses from human middle ears.

Results:
Histologic studies show the material's surface covered with regular mucosa and submucosal connective tissue. An inflammatory reaction was seen in the early postoperative stage in the animal study and in chronic middle ear disease in humans. High cylindrical epithelium with ciliated and goblet cells was detected. In no cases there were round cells adjacent to the biomaterial's surface. The results show good acceptance of titanium in the animal model as in human application as well.

Schwager K. Epithelisierung von Titanprothesen im Mittelohr des Kaninchens. Modellvorstellungen zur Mukosaentwicklung. Laryngo-Rhino-Otol 77, 38-42 (1998)

Schwager K. Titanium as an ossicular replacement material: Results after 336 days of implantation in the rabbit. Am J Otol 19, 569-573 (1998)

Geyer G, Städtgen A, Schwager K, Jonck L. Ionomeric cement implants in the middle ear of baboons (Papio ursinus). Eur Arch Otorhinolaryngol 225, 402-409 (1998)

Schwager K, Geyer G. Titanium and Glass-ionomer cement as ossicular replacement materials: biocompatibility results after implantation in the rabbit. ORL 60, 322-328 (1998)

Schwager K. Titanium - a biomaterial for ossicular replacement: Results after implantation in the middle ear of the rabbit. Eur Arch Otorhinolaryngol 225, 396-401 (1998)

Schwager K. Mittelohrprothesen und das biologische Umfeld. Biomaterialien 1 (1), 42-47 (2000)

Schwager K. Rasterelektronenmikroskopische Befunde an Titan-Mittelohrprothesen Laryngo-Rhino-Otol 79, 762-766 (2000)

Schwager K. Stand der Implantologie in der HNO-Heilkunde. Nova Acta Leopoldina 84, 322, 83-98 (2001)

Brors D, Aletsee C, Schwager K, Mlynski R, Hansen S, Schäfers M, Ryan AF, Dazert S. Interaction of spiral ganglion processes with alloplastic materials in vitro. Hearing Research 167, 110-121 (2002)

Schwager K. Titan als Material für die Rekonstruktion der Gehörknöchelchenkette - Eine experimentelle Studie, In: Hagen R, Geyer G, Helms J. Knochenersatz in der Mittelohr-und Schädelbasischirurgie, Chirurgie, vol 1, 66-69, Sympomed, München (1996)

Schwager K. Titanium in ossicular reconstruction. Morphological results in animal experiments and after implantation in the human middle ear. The Second International Symposium on Middle-Ear Mechanics in Otosurgery. Boston October 21-24 (1999)

Equipment:
Light microscopy, scanning electrone microscopy (Lehrstuhl Zoologie I)