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Third-party-funded project

Title:
Functional contribution of humoral and cellular immune responses to Campylobacter jejuni in the pathogenesis of immune-mediated neuropathies

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The Guillain-Barré Syndrome is an acute radiculoneuritis, causes flaccid generalized paresis, and frequently occurs after infectious diseases. Campylobacter jejuni has been identified as the most common infectious agent. There is evidence that the humoral immune response against C. jejuni crossreacts with antigens of the peripheral nervous system (PNS) whereas it is unproven that molecular mimicri contributes to the development of neuritis or paresis.
The project revealed in macro-patch clamp experiments with murine hemidiaphragms that polyclonal immune sera of rats immunized with C. jejuni and a generated monoclonal antibody specific for C. jejuni LPS impaired neuromuscular transmission. Human C. jejuni-specific T-lymphocyte lines were generated some of which were crossreactive to myelin protein from the PNS. Finally, in vivo experiments in an animal model of GBS, experimental autoimmune neuritis of the Lewis rat (EAN), demonstrated that enteral LPS from C. jejuni can prevent oral tolerization to myelin and EAN, but instead accelerates onset of EAN.

Key words:
    Guillain-Barré syndrome
    molekular mimicri
    campylobacter jejuni
    autoimmunity
    PNS

Projekt period: from 05.1999 to 01.2002

Funding institution:
Sondermittel Land Bayern ,Granting date: 01.04.1999
Landeshaushalt Wissenschaftsministerium ( IZKF )

Preceding project:
keines

Publications:

Links:
IZKF