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Third-party-funded project

Title:
Novel mechanisms of cell communication in the nervous system:
Physiology and function of the p75 neurotrophin receptor"

Project management at the University of Würzburg:

• PD. Dr. med. Martin Koltzenburg , bis 01/2002, jetzt Institute of Child Health University College London

Participating scientists:

• Dr. med. Klaus Schmidt

Abstract:
The role of p75NTR in mediating the regulatory effects of neurotrophins on noxious heat and capsaicin sensitivity will be investigated using cell culture systems as well as analysis of cuteneous sensory neurons in situ. In addition to comparisons between wild type and p75NTR knock-out preparations, the specific role of p75NTR in these processes will be studied using mutant ligands deficient in p75NTR binding and purified preparations. The objective of this project will be to translate the fundamental knowledge that has been derived from reduced cellular systems to functional studies in the adult nervous system nociceptive pathways.

Key words:
    Pain
    neurotrophins
    capsaicin
    sensory neurons
    mouse mutants

Projekt period: from 02.2000 to 01.2003

Funding institution:
EU ,Granting date: 10.01.2000

Preceding project:
SFB 353, B13

Publications:

• Stucky, C. L., Koltzenburg, M.. (1997). The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. Journal of Neuroscience, 8,178. (scientific article)
• Stucky, C. L., Koltzenburg, M., Schneider, M., Engel, M. G., Albers, K. M., Davis, B. M.. (1999). Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors. Journal of Neuroscience, 8,178. (scientific article)
• Caterina M.J. Leffler A., Malmberg A. B., Martin W. J., Trofton J., Petersen-Zeitz K. R., Koltzenburg M., Basbaum A. I., Julius D.. (2000). Impaired nocicephion and pain sensation in mice lacking the capsaicin receptor. Science, 23,329. (scientific article)
• Bendszus M, Koltzenburg M.. (2001). Visualization of denervated muscle by gadolinium-enhanced MRI. Neurology, 5,212. (scientific article)
• Bendszus M, Beck A, Koltzenburg M, Vince GH, Brechtelsbauer D, Littan T, Urbach H, Solymosi L.. (2001). MRI in isolated sixth nerve palsies. Neuroradiology, 1,097. (scientific article)
• Koltzenburg M, Scadding J.. (2001). Neuropathic pain. Curr Opin Neurol, 4,035. (scientific article)
• Du J, Koltzenburg M, Carlton SM.. (2001). Glutamate-induced excitation and sensitization of nociceptors in rat glabrous skin.. Pain, 4,541. (scientific article)