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Third-party-funded project

Title:
Regulation of the phenotype of sensory neurons

Project management at the University of Würzburg:

• PD Dr. med. Martin Koltzenburg , (bis 1/2001, danach University College, London),Tel: 0931/201-23751,Fax: 0931/201-23697

Participating scientists:

• PD Dr. med. Claudia Sommer ,Tel: 0931 201 23763,Fax: 0931 201 23763,Mail: sommer@mail.uni-wuerzburg.de
• Prof. Dr. med. Klaus V. Toyka ,Tel: 0931 201 23751,Fax: 0931 201 23946,Mail: k.toyka@mail.uni-wuerzburg.de
• Dr. med. Annette George ,Tel: 0931 201 23751,Fax: 0931 201 23946

Abstract:
The sensitization of nociceptors by tissue inflammation and nerve lesions is the pathologic hallmark of chronic pain and hyperalgesia. The voltage gated ion channels and receptors for transmitters and co-transmitters seem to be directly linked to the development of pain and hyperalgesia. Neurotrophins and cytokines are important for receptor and channel regulation. The investigation aims at characterizing these features in nerve-skin preparations and in isolated dorsal root ganglion cells.

Key words:
    Sensory neurons
    dorsal root ganglial cells
    pain
    hyperalgesia
    neurotrophic factors

Projekt period: from 01.1999 to 12.2000

Funding institution:
DFG ,Granting date: 02.12.1994

Preceding project:
SFB 353, B13, 1. Förderperiode

Publications:

• Carroll P., Lewin G.R., Koltzenburg M., Toyka K. V., Thoenen H.. (1998). A role of BDNF in mechano sensation. Nat. Neurosci., 15,668. (scientific article)
• Caterina M.J. Leffler A., Malmberg A. B., Martin W. J., Trofton J., Petersen-Zeitz K. R., Koltzenburg M., Basbaum A. I., Julius D.. (2000). Impaired nocicephion and pain sensation in mice lacking the capsaicin receptor. Science, 23,329. (scientific article)
• Koltzenburg M., Bennett, D.L.H., Shelton, D.L., McMahon S. B.. (1999). Neutrasisation of NGF prevents the sensitisation of nociceptors innervating inflamed skin. European Journal of Neuroscience, 3,919. (scientific article)
• Stucky, C. L., Koltzenburg, M.. (1997). The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. Journal of Neuroscience, 8,178. (scientific article)
• Stucky, C. L., Koltzenburg, M., Schneider, M., Engel, M. G., Albers, K. M., Davis, B. M.. (1999). Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors. Journal of Neuroscience, 8,178. (scientific article)
• Koltzenburg M,. (2000). Neural mechanisms of cutaneous nociceptive pain.. Clin J Pain, 1,613. (scientific article)
• Berg D, Weishaupt A, Francis MJ, Miura N, Yang XL, Goodyer ID, Naumann M, Koltzenburg M, Reiners K, Becker G,. (2000). Changes of copper-transporting proteins and ceruloplasmin in the lentiform nuclei in primary adult-onset dystonia.. Ann Neurol, 8,481. (scientific article)
• Kinkelin I, Brocker EB, Koltzenburg M, Carlton SM.. (2000). Localization of ionotropic glutamate receptors in peripheral axons of human skin. Neurosci Lett, 2,021. (scientific article)
• Bendszus M, Koltzenburg M.. (2001). Visualization of denervated muscle by gadolinium-enhanced MRI. Neurology, 5,212. (scientific article)
• Bendszus M, Beck A, Koltzenburg M, Vince GH, Brechtelsbauer D, Littan T, Urbach H, Solymosi L.. (2001). MRI in isolated sixth nerve palsies. Neuroradiology, 1,097. (scientific article)
• Koltzenburg M, Scadding J.. (2001). Neuropathic pain. Curr Opin Neurol, 4,035. (scientific article)
• Du J, Koltzenburg M, Carlton SM.. (2001). Glutamate-induced excitation and sensitization of nociceptors in rat glabrous skin.. Pain, 4,541. (scientific article)