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Third-party-funded project

Title:
Role of microglial cells and peripheral nerve macrophages in gerneticall-mediated demyelination

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Animal models for inherited peripheral neuropathies are important tools to study putative common pathological pathways in the different subtypes of the corresponding human disorders. We could show that in two different myelin mutants the first histopathological changes is the elevation of the number of nerve macrophages. These macrophages play a pivotal role during the primarily genetically-induced demyelination. The inactivation of nerve macrophages may be an important approach to treat different subtypes of inherited neuropathies.

Key words:
    Neuropathy
    myelin deficiency
    axonal loss
    macrophages
    animal models
    modulating factors of inherited disease
    therapy

Projekt period: from 07.2001 to 06.2003

Funding institution:
DFG ,Granting date: 21.06.2001

Publications: