Role of microglial cells and peripheral nerve macrophages in gerneticall-mediated demyelination
Project management at the University of Würzburg:
Animal models for inherited peripheral neuropathies are important tools to study putative common pathological pathways in the different subtypes of the corresponding human disorders. We could show that in two different myelin mutants the first histopathological changes is the elevation of the number of nerve macrophages. These macrophages play a pivotal role during the primarily genetically-induced demyelination. The inactivation of nerve macrophages may be an important approach to treat different subtypes of inherited neuropathies.
modulating factors of inherited disease
from 07.2001 to 06.2003
DFG ,Granting date: 21.06.2001
- Schmid C.D., Stienekemeier M., Oehen S., Bootz F., Zielasek J., Gold R., Toyka K.V., Schachner M., Martini R..
(2000). Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance.. J Neurosci, 8,178. (scientific article)
- Carenini S., Mäurer M., Werner A., Blazyca H., Toyka K.V., Schmid C.D., Raivich G., Martini R..
(2001). The role of macrophages in demyelinating peripheral nervous system of mice heterozygously deficient in P0.. J Cell Biol, 12,915. (scientific article)
- Mäurer M, Schmid CD, Bootz F, Zielasek J, Toyka KV, Oehen S, Martini R..
(2001). Bone marrow transfer from wild type mice reverts the beneficial effect of genetically-mediated immune deficiency in myelin mutants.. Mol Cell Neurosci, 5,446. (scientific article)
- Kobsar I, Mäurer M, Ott T, Martini R..
(2002). Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32.. Neurosci. Lett., 2,021. (scientific article)
- Igor Kobsar, Martin Berghoff, Mohtashem Samsam, Carsten Wessig..
(in press). Preserved myelin integrity and reduced axonopathy in connexin 32.. Brain, 7,407. (scientific article)