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Third-party-funded project

Title:
Neuritogenic capacity of immune cells and inducibility of peripheral nerve inflammation in animal models for inherited neuropathies

Project management at the University of Würzburg:

Participating scientists:

Abstract:
T-lymphocytes are important modulators for primarily geneticall-mediated demyelination in the peripheral nervous system of mouse models for inherited neuropathies. A first aim of the project is to investigate whether immune cells of the mouse models recognize peripheral nerve myelin components as antigens. Furthermore, it will be studied whether immune cells from the animal models can induce nerve inflammation in wild type mice. In addition, it is of interest whether the mutants are more susceptible for peripheral nerve inflammation than wild type mice. The analysis of the pathological impact of the immune cells of the myelin mutants as well as their susceptibility for peripheral nerve inflammation may open the access to novel experimental and clinical treatment studies for inherited neuropathies.

Key words:
    Neuropathy
    myelin deficiency
    axonal loss
    macrophages
    lymphocytes
    animal models
    experimental allergic neuritis (EAN)
    modulating factors of inherited disease
    therapy

Projekt period: from 12.1998 to 11.2000

Funding institution:
Sonstige Stiftung ( Gemeinnützige Hertie-Stiftung, Frankfurt/M. ) ,Granting date: 26.08.1998

Publications: