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Third-party-funded project

Title:
Vector-mediated expression of trophic factors for axon rescue in animal models for inherited neuropathies

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Inherited demyelination often leads to a substantial loss of axons that causes serious clinical features, such as muscle weakness and eventually muscle wasting. In order to mitigate demyelination-related axonal loss, application of trophic factors might be a promising approach. For this purpose, established adeno-viral vectors expressing trophic factors (e.g., NT-3) will be injected into muscles of mice mimicking severe forms of inherited neuropathies.

Key words:
    Neuropathy
    myelin deficiency
    axonal loss
    macrophages
    trophic factors
    expression vector
    animal models
    therapy

Projekt period: from 02.2000 to 01.2002

Funding institution:
Sonstige Stiftung ( Gemeinnützige Hertie-Stiftung, Frankfurt/M. ) ,Granting date: 04.01.2000

Publications: