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Third-party-funded project

Title:
The role of p75 NTR in modulating neurotrophin survival effects in developing motoneurons

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The p75 Neurotrophin receptor can actively mediate cell death of developing neurons. We have investigated survival of isolated motoneurons from wildtype and p75-/- mice, and could show that lack of p75 does not influence survival, but specificity and high affinity binding of neurotrophins. These data show that p75 plays an important role as a co-receptor for those neurons which express significant levels of trkB.

Key words:
    Cell death
    Apoptosis
    Motoneuron
    Neurotrophins

Projekt period: from 10.1996 to 01.1998

Funding institution:
DFG ( SFB 465 TP A3 ) ,Granting date: 16.06.1999

Publications:

Links:
Institute for Clinical Neurobiology