The role of p75 NTR in modulating neurotrophin survival effects in developing motoneurons
Project management at the University of Würzburg:
The p75 Neurotrophin receptor can actively mediate cell death of developing neurons. We have investigated survival of isolated motoneurons from wildtype and p75-/- mice, and could show that lack of p75 does not influence survival, but specificity and high affinity binding of neurotrophins. These data show that p75 plays an important role as a co-receptor for those neurons which express significant levels of trkB.
Projekt period: from 10.1996 to 01.1998
DFG ( SFB 465 TP A3 ) ,Granting date: 16.06.1999