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Third-party-funded project

Title:
Immunoregulatory mechanisms in Multiple Sklerosis: Modulation of apoptosis in t-cell mediated immune responses

Project management at the University of Würzburg:

• Prof. Dr. med. Klaus Toyka ,Tel: 0931/201-23751,Fax: 0931/201-23697,Mail: Toyka_K@klinik.uni-wuerzburg.de

Participating scientists:

• Prof. Dr. med. Ralf Gold ,Tel: 0931/201-23755,Fax: 0931/201-23488,Mail: r.gold@mail.uni-wuerzburg.de
• Dr. med. Verena Leussink
• Dr. med. Andrew Chan

Abstract:
In immune mediated acute inflammatory neuropathies the T-cell-infiltration is an important first step. After transmigration of T-cells into the nerve parenchyma the inflammatory response must be terminated. T-cell apoptosis is a central mechanism to eliminate T-cells. The project deals with the mechanisms and regulatory signals of T-cell apoptosis. The grant provides the principal investigator with support to carry out this project.

Key words:
    Guillain-Barré Syndrome
    EAN
    T cell apoptosis
    nerve inflammation

Projekt period: from 07.1999 to 12.1999

Funding institution:
Sonstige Stiftung ( Gemeinnützige Hertie-Stiftung ) ,Granting date: 24.06.1999

Preceding project:
keines

Publications:

• 1. Schneider, Ch., M. C. Dalakas, K. V. Toyka, G. Said, H.-P. Hartung, R. Gold. (1999). T cell apoptosis is not augmented in inflammatory neuromuscular disorders associated with HIV-Infection. Archives of Neurology, 4,053. (scientific article)
• 2. Weishaupt, A., S. Jander, W. Brück, T. Kuhlmann, M. Stienekemeier, T. Hartung, K. V. Toyka, G. Stoll, R. Gold. (2000). Molecular mechanisms of high-dose antigen therapy in experimental autoimmune encephalomyelitis: Rapid induction of Th1 type cytokines and iNOS. Journal of Immunology, 7,065. (scientific article)
• 3. Weishaupt, A., R. Gold, T. Hartung, S. Gaupp, A. Wendel, W. Brück, K. V. Toyka. (2000). Role of TNF in high-dose antigen therapy in experimental autoimmune neuritis: inhibition of TNF-alpha by neurtalizing antibodies reduces T-cell apoptosis and prevents liver necrosis. Journal of Neuropathology and Experimental Neurology, 5,533. (scientific article)
• 4. Wohlleben G., S. M. Ibrahim, J. Schmidt, K. V. Toyka, H.-P. Hartung, R. Gold. (2000). Regulation of Fas und FasL expression on rat Schwann cells. Glia, 4,193. (scientific article)
• 5. Chan, A., T. Magnus, R. Gold, K. V. Toyka. (2001). Phagocytosis of apoptotic inflammatory cells by microgliy and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system. Glia, 4,193. (scientific article)
• 6. Weishaupt, A., L. M. Schönrock, M. Stienekemeier, K. V. Toyka. (2001). Glucocorticosteroids modulate antigen-induced T-cell apoptosis in experimental autoimmune neuritis and cause T-cell proliferation in suti. Acta Neuropathologica, 2,165. (scientific article)