Modulation of experimental autoimmune encephalomyelitis by glatirameracetate
Project management at the University of Würzburg:
The polypeptide Glatirameracetate (GLAT) resembles the myelin basic protein (MBP) which is assumed to be one target of the autoimmune inflammatory attack during multiple sclerosis. In relapsing-remitting multiple sclerosis patients GLAT reduces the frequency of relapses. The immunomodulatory mechanisms of GLAT are not fully understood.
The in vitro findings of the project suggest that GLAT does not only act at the T cell level but also modulates immunoreactivity of phagocytes and antigen presenting cells: GLAT suppressed TNF-alpha production and enhanced IL-10 production by rat macrophages. In the presence of GLAT rat dendritic cells, human monocytes, and human dendritic cells produced higher amounts of both cytokines.
Projekt period: from 01.2000 to 12.2000
Wirtschaftsunternehmen ,Granting date: 08.12.1999