Neurologische Klinik und Poliklinik
Josef-Schneider-Str. 11, 97080 Würzburg
Other participating persons and organisations:
Research foci (and basic equipment-based research projects):
The main focus of the research group is on the pathophysiology of dystonia and Parkinson´s disease. Functional imaging studies (fMRI, PET), transcranial sonography (TCS), electrophysiological tests, and studies on copper storage in brain tissue are performed in order to obtain further insights into the sensorimotor integration and morphological alterations in movement disorders (Parkinson‘s disease, dystonia), and to enable presymptomatic diagnosis of Parkinson´s disease. The pattern of cognitive dysfunction and depression in various Parkinsonian syndromes are further research areas. New concepts in the treatment of autonomous disorders using botulinum toxin and novel strategies to prevent antibody formation are developed.
Dystonia: SPECT and CS studies have identified the basal ganglia as the critical anatomical area involved in the pathophysiology of dystonias. Neurochemical studies demonstrated an increased copper content in the pallidum. Overactivity of motor cortical areas which may be modulated by sensory tricks has been shown in fMRI and PET studies.
Parkinson´s disease: Distinct cognitive deficits in various parkinsonian syndromes were identified using extensive neuropsychological testing. TCS is a promising tool to detect substantia nigra degeneration at early stages of PD.
Botulinum toxin: New indications for BTX use in autonomic disorders have been developed and large controlled clinical trials were performed in focal hyperhidrosis.