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Research focus:  

Neurologische Klinik und Poliklinik
Josef-Schneider-Straße 11, 97080 Würzburg
Mail: Toyka_K@klinik.uni-wuerzburg.de
Url: http://www.neurologie.uni-wuerzburg.de/

Scientific members:

   Professors:

   Outside lecturer:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
The main interest of the clinical research group is focused on clinically relevant topics and on more basic experimental projects. Each year about 1500 patients with multiple sclerosis and other neuro- immunological disorders are seen in our department. Many patients are referred from other neurologists to obtain expert opinion concerning immunotherapy. The group participates in several multicenter treatment trials in multiple sclerosis and other neuroimmunological disorders. Members of the group are actively engaged in the Medical Advisory Board of the German MS Society and give both expert opinion and recommendations concerning relevant topics inside and outside the country.

Basic research is focused on the cytokine network and regulatory mechanisms in MS, experimental immunotherapies and mechanisms which control the transmigration of immune cells across the blood-brain-barrier. Specific PCR techniques were developed which allow reliable quantification of mRNA. Also, cytokine analyses from several multicenter studies are performed in our laboratory. The experimental goals are focused on the introduction of novel and more specific immunotherapies and on mechanisms of T cell elimination. A number of studies dealing with T cell apoptosis in experimental autoimmune disorders and human neuroimmunological diseases were conducted. Moreover, induction of oral tolerance, systemic antigen therapy and studies to block adhesion molecules are subjects of the research.
New areas of research are the influence of modulating genes on course and severity of MS and EAE. This work is performed in close cooperation with the Institute for Clinical Neurobiology (®link).

Besides multiple sclerosis, studies on the pathogenesis and therapy of myasthenia and polyneuritis (GBS and CIDP) are in the focus of the clinical research group, including participation in international trials.

The group receives financial support from the German Research Association and from other third-party granting agencies, but is also involved in the program for clinical research (IZKF) at the University of Würzburg.

Financial Support:
German Research Community (DFG),
German Ministry for Research and Technology (BMFT/BMBF),
German Multiple Sclerosis Society (DMSG),
State of Bavaria and University of Würzburg (Universität Würzburg),
Wilhelm-Sander-Stiftung,
Gemeinnützuge Hertie-Stiftung,
Centre for Clinical Research at the University of Würzburg (IZKF).

Results:
see research projects (Gold, Rieckmann, Toyka)

Rewards and prizes:
Wartenberg Lecture DGN 2000 PD Rieckmann,
Queckenstedt Award 1999 PD Rieckmann,
Langheinrich Award 1997 PD Gold (given in 1999),
Rhône-Poulenc-Rorer Award 1999 Dr. Buchwald.

Equipment:
**

Links:
Institute for Clinical Neurobiology