Research focus: |
Klinik und Poliklinik für Psychiatrie und Psychotherapie
Füchsleinstr. 15, 97080 Würzburg Mail: boening@mail.uni-wuerzburg.de Url: |
Scientific members:
Professors:
Outside lecturer:
Scientific assistants:
Research foci (and basic equipment-based research projects):
Wuerzburg BMBF Addiction Research Association on "the neurobiological and behavioral-biological basics of alcohol dependence as well as alcohol/drug craving in biologically defined high-risk groups with relevance to relapse prevention strategies."
Results:
Several symposia at international congresses derived from the scientific activities of the Wuerzburg BMBF Addiction Research Association and almost 100 papers were published in international peer-review journals:
(1) Altemus M, Murphy DL, Greenberg B, Lesch KP (1996) Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder. Am J Med Genetics, 67, 409-411
(2) Bendszus M, Weijers H-G, Wiesbeck GA, Warmuth-Metz M, Bartsch AJ, Engels S, Böning J & Solymosi L (2001) Sequential MR Imaging and Proton MR Spectroscopy in patients who underwent recent detoxification for chronic alcoholism: Correlation with clinical and neuropsychological data. American Journal of Neuroradiology, 22, 1926-1930.
(3) Bengel D, Heils A, Seemann L, Petri S, Teufel A, Andrews A, Riederer P, Murphy DL & Lesch KP (1997) Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. Mol Brain Res, 44, 286-293
(4) Bengel D, Murphy DL, Andrews AM, Wichems CH, Feltner D, Heils A, Mössner R, Westphal H & Lesch KP (1998) Altered brain serotonin (5-HT) homeostasis and locomotor insensitivity to MDMA ("ecstasy") in 5-HT transporter-deficient mice. Mol Pharmacol, 53, 649-655
(5) Bennett AJ, Lesch KP, Heils A, Long J, Lorenz J, Shoaf SE, Champoux M, Suomi SJ, Linnoila M, Higley JD (2001) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry (in press)
(6) Bleich S, Degner D, Bandelow B, von Ahsen N, Rüther E, Kornhuber J (2000) Plasma homocysteine is a predictor for ethanol withdrawal seizures. NeuroReport, 11, 2749-2752
(7) Bleich S, Degner D, Kropp S, Rüther E, Kornhuber J (2000) Red wine, spirits, beer and serum homocysteine. Lancet, 356, 512
(8) Bleich S, Degner D, Wiltfang J, Maler JM, Niedmann P, Cohrs S, Mangholz A, Porzig J, Sprung R, Rüther E, Kornhuber J (2000) Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcoholism, 35, 351-354
(9) Bleich S, Spilker K, Kropp S, Degner D, Rüther E, Kornhuber J (2000) Elevated homocysteine levels in social drinkers. How to explain the "french paradox"? Alcohol Alcoholism, (in press)
(10) Bleich S, Spilker K, Kurth C, Degner D, Quintela-Schneider M, Javaheripour K, Rüther E, Kornhuber J, Wiltfang J (2000) Oxidative stress and an altered methionine metabolism in alcoholism. Neurosci.Lett., 286, 171-174
(11) Kurth C, Wegerer V, Kornhuber J, Paulus W, Bleich S (2001) Risk assessment of alcohol withdrawal seizures with a Kohonen feature map. Neurosci.Lett., (in press)
(12) Bleich S, Degner D, Javaheripour K, Kornhuber J (2000) Homocysteine and alcoholism. J.Neural Transm.Suppl., 60, 187-196
(13) Blum-Degen D, Heinemann T, Lan J, Pedersen V, Leblhuber F, Paulus W, Riederer P & Gerlach M (1999) Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing. Brain Res, 834, 128-135
(14) Böning J (2001) Neurobiology of an addiction memory. J.Neural Transm., 108, 755 -765
(15) Böning J, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA (2001) Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism: Clinical and Experimantal Research, 25, 127S-131S
(16) Böning J, Weijers H-G & Herrmann MJ (2002) Suchtgedächtnis und Cue-Reaktivität ? eine neuropsychobiologische Synopsis. Psychomed, 14, 74-80
(17) Champoux M, Bennett A, Lesch KP, Heils A, Nielsen DA, Higley JD & Suomi SJ (2001) Serotonin transporter gene polymorphism and neurobehavioral development in rhesus monkey neonates. Soc Neurosci Abstr, (in press)
(18) Collier DA, Stöber G, Li T, Heils A, Catalano M, Di Bella D, Arranz MJ, Murray RM, Vallada HP, Bengel D, Müller CR, Roberts GW, Smeraldi E, Kirov G, Sham P, Lesch KP (1996) Susceptibility to bipolar affective disorder and unipolar depression is influenced by allelic variation of functional serotonin transporter expression. Mol Psychiatry, 1, 453-460
(19) Di Bella D, Catalano M, Balling U, Smeraldi E, Lesch KP (1996) Systematic screening for muataions in the coding region of the human serotonin transporter (5HTT) using PCR and DGGE. Am J Med Genetics, 67, 541-545
(20) Fabre V, Beaufour C, Evrard A, Rioux A, Hanoun N, Lesch KP, Murphy DL, Lanfumey L, Hamon M, Martres MP (2000) Altered expression and functions of the serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci, 12, 2299-2310
(21) Fallgatter A, Wiesbeck GA, Weijers H-G, Böning J & Strik WK (1998) Event-related correlates of response suppression as indicators of novelty seeking in alcoholics. Alcohol & Alcoholism, 33, 475-481
(22) Fallgatter AJ, Jatzke S, Bartsch AJ, Hamelbeck B, Lesch KP (1999) Serotonin transporter promoter polymorphism influences topography of inhibitory motor control. Int J Neuropsychopharm, 2,115-120
(23) Fleischmann H, Wodarz N (1999) "Chronisch mehrfach beeinträchtigte Alkoholabhängige" - Anwendbarkeit und psychometrische Aspekte eines Vorschlages zur operationalisierten Diagnostik. Sucht, 45, 34-44
(24) Gerlach M, Blum-Degen D, Lan J & Riederer P (1999) The role of nitric oxide in the pathogenesis of Parkinson´s disease. Adv Neurol, 80, 239 - 245
(25) Gerlach M, Blum-Degen D, Ransmayr G, Leblhuber F, Pedersen V & Riederer P (2001) Expression, but not activity, of neuronal NOS is regionally increased in the alcoholic brain. Alcohol and Alcoholism, 36, 65-69
(26) Gerlach M, Oehler D, Blum-Degen D, Lange KW, Mayer B, Reichmann H & Riederer P (1995) Regional distribution and characterization of nitric oxide synthase activity in the brain of the common marmoset. NeuroReport, 6, 1141-1145
(27) Gobbi G, Lesch KP, Murphy DL, Blier P (2001) Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. J Pharmacol Exp Ther, 296, 987-995
(28) Götz ME, Janetzky B, Pohli S, Gottschalk A, Gsell W, Tatschner T, Ransmayr G, Leblhuber F, Gerlach M, Reichmann H, Riederer P & Böning J (2001) Chronic alcohol consumption and cerebral indices of oxidative stress: Is there a link? Alcoholism: Clin Exp Res, 25, 717-725
(29) Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL (2000) Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genetics, 96, 202-216
(30) Haen E, Wodarz N (1999) Pharmakologie der Suchtstoffe. Internist, 40, 605-610
(31) Hashimoto E, Frölich L, Ozawa H, Saito T, Shichinohe S, Takahata N & Riederer P (1996) Alteration of glutamyl-transpeptidase binding proteins in post mortem brains of heroin addicts. Alcoholism: Clinical and Experimental Research, 20, 301-304
(32) Hashimoto E, Frölich L, Ozawa H, Saito T, Maurer K, Böning J, Takahata N & Riederer P (1998) Reduced immunoreactivity of type I adenylyl cyclase in the post mortem brains of alcoholics. Alcoholism: Clinical and Experimental Research, 22, 88-92
(33) Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D & Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem, 66, 2621-2624
(34) Heils A, Wichems C, Mössner R, Petri S, Glatz K, Bengel D, Riederer P, Murphy DL, Lesch KP (1998) Functional characterization of the murine serotonin transporter gene promoter in serotonergic raphe neurons. J Neurochem, 40, 932-939
(35) Heinz A, Higley JD, Gorey JG, Saunders R, Jones DW, Saunders R, Zajicek K, Suomi SJ, Lesch KP, Weinberger DR & Linnoila M (1998) In vivo association between alcohol intoxication, aggression and serotonin transporter availability in non-human primates. Am J Psychiatry, 155, 1023-1028
(36) Herrmann MJ, Weijers H-G, Wiesbeck GA, Aranda D, Böning J & Fallgatter AJ (2001) Event-related potentials and cue-reactivity in alcoholism. Alcoholism: Clinical and Experimental Research, 24, 1724-1729
(37) Herrmann MJ, Weijers H-G, Wiesbeck GA, Böning J & Fallgatter AJ (2001) Alcohol cue-reactivity in heavy and light social drinkers as revealed by event-related potentials. Alcohol & Alcoholism, 36, 164-172
(38) Herrmann MJ, Sonnek G, Weijers H-G, Wiesbeck GA, Böning J & Fallgatter AJ (2002) Electrophysiological indication for a link between serotonergic neurotransmission and personality in alcoholism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 26, 157-161
(39) Ibarra C, Nedvetsky PI, Gerlach M, Riederer P, Schmidt HHHW (2001) Regional and age-dependent expression of the nitric oxide receptor, soluble guanylyl cyclase, in the human brain. Brain Res, (in press)
(40) Kornhuber J, Jellinger K, Wiltfang J, Leblhuber F & Riederer P (2001) The N-methyl-D-aspartate receptor channel blocker amantadine does not cause histological alterations in human brain tissue. Acta Neuropathol, (in press)
(41) Kornhuber J & Weller M (1996) Neue therapeutische Möglichkeiten mit niederaffinen NMDA-Rezeptorantagonisten. Nervenarzt, 67, 77?82
(42) Kornhuber J & Weller M (1997) Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry, 41, 135?144
(43) Kroemer RT, Koutsilieri E, Hecht P, Liedl KR, Riederer P & Kornhuber J (1998) Quantitative analysis of the structural requirements for blockade of the NMDA receptor at the PCP binding site. J Med Chem, 41, 393?400.
(44) La Cour CM, Boni C, Hanoun N, Lesch KP, Hamon M, Lanfumey L (2001) Functional consequences of 5-HT transporter gene disruption on 5-HT1A receptor-mediated regulation of dorsal raphe and hippocampal cell activity. J Neurosci, 21, 2178-2185
(45) Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH & Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1483-1487
(46) Lesch KP, Jatzke S, Meyer J, Stöber G, Okladnova O, Mössner R, Riederer P (1999) Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression. J Neural Transm, 106,1223-1230
(47) Lesch KP, Meyer J, Glatz K, Flügge G, Hinney A, Hebebrand J, Klauck S, Poustka F, Poustka A, Bengel D, Mössner R, Riederer P, Heils A (1997) The 5-HT transporter gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. J Neural Transm, 104,1259-1266
(48) Li Q, Wichems C, Heils A, Lesch KP, Murphy DL (2000) Reduction in density, but not G protein coupling, of 5-HT1A receptors in 5-HT transporter mutation mice: gender and brain differences. J Neurosci, 20, 7888-7895
(49) Li Q, Wichems C, Heils A, Van de Kar LD, Lesch KP, Murphy DL (1999) Reduction of 5-HT1A mediated temperature and neuroendocrine responses and 5-HT1A binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Therap, 291, 999-1007
(50) Meyer J, Wiedemann P, Okladnova O, Brüss M, Staab T, Stöber G, Riederer P, Bönisch H, Lesch KP (1998) Cloning and functional characterization of the human norepinephrine transporter gene promoter. J Neural Transm, 105,1341-1350
(51) Mössner R, Albert D, Persico AM, Henning T, Bengel D, Holtmann B, Schmidt A, Keller F, Simantov R, Murphy DL, Seif I, Deckert J, Lesch KP (2000) Differential regulation of adenosine A1 and A2A receptors in serotonin transporter and monoamine oxidase-deficient mice. Eur J Neurospsychopharm, 10, 489-493
(52) Okladnova O, Syagailo YV, Mössner R, Riederer P, Lesch KP (1998) Regulation of human PAX-6 gene transcription: alternate promoter usage in human brain. Mol Brain Res, 60,177-192
(53) Okladnova O, Syagailo YV, Tranitz M, Stöber G, Riederer P, Mössner R & Lesch KP (1998) A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain. Biochem Biophys Res Comm; 248,402-405
(54) Okladnova O, Syagailo YV, Tranitz M, Stöber G, Riederer P, Mössner R & Lesch KP (1999) Regulation of human PAX-3 gene transcription in human brain. Genomics, 57,110-119
(55) Ozawa H, Katamura Y, Hatta S, Saito T, Katada T, Gsell W, Frölich L, Takahata N & Riederer P (1993) Alterations of guanine nucleotide binding proteins in post-mortem human brain in alcoholics. Brain Res, 620, 174-179
(56) Ozawa H, Saito T, Hatta S, Hashimoto E, Frölich L, Ohshika H, Takahata N & Riederer P (1994) Reduced sensitivity to ethanol of Gs and Gi/o in the cerebral cortex of alcoholic patients. Alcohol & Alcoholism, 29 (S1), 93-97
(57) Persico AM, Mengual E, Mössner R, Revay RS, Sora I, Arellano J, DeFelipe J, Gimenez-Amaya JM, Marino R, Cabib S, Pascucci T, Uhl GR, Murphy DL, Lesch KP, Keller F (2001) Barrel pattern formation requires serotonin uptake by thalamocortical endings, while vesicular monoamine release is necessary for development of supragranular layers. J Neurosci (in press)
(58) Reiff A, Keller H, Schneider M, Kamolz S, Schmidtke A & Fallgatter AJ (2001) Carbohydrate-deficient transferrin is elevated in catabolic female patients. Alcohol & Alcoholism, 36, 603-607
(59) Rioux A, Fabre V, Lesch KP, Mössner R, Murphy DL, Lanfumay L, Hamon M & Martres MP (1999) Adaptive changes of serotonin 5-HT2A receptors in mice lacking the serotonin transporter. Neurosci Letters, 262,113-116
(60) Salichon N, Gaspar P, Upton AL, Hamon M, De Maeyer E, Picaud S, Murphy DL, Mössner R, Lesch KP, Hen R, Seif I (2001) Excessive activation of 5-HT1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knock-out mice. J Neurosci, 21, 884-896
(61) Samochowiec J, Lesch KP, Rottmann M, Smolka M, Syagailo YV, Okladnova O, Rommelspacher H, Winterer G, Schmidt LG & Sander T (1999) Association of a regulatory polymorphism in the promoter region of the monoamine oxidase A gene with antisocial alcoholism. Psychiatric Res, 86, 67-72
(62) Samochowiec J, Rottmann M, Okladnova O, Syagailo Y, Sander T, Mühlbauer E, Smolka M, Tranitz M, Rommelspacher H, Schmidt LG & Lesch KP (1999) Association analysis of a functional repeat polymorphism within the promoter region of human PAX-6 gene with alcohol dependence. Addiction Biol, 4, 323-328
(63) Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H & Schmidt LG (1997) Possible genotypic association of a regulatory variant of the serotonin transporter gene with severe alcohol dependence. Alcohol Clin Exp Res, 21, 1356-1359
(64) Sander T, Harms H, Lesch KP, Dufeu P, Kuhn S, Hoehe M, Rommelspacher H & Schmidt LG (1998) Serotonin transporter gene variants in alcohol-dependent subjects with dissocial personality disorder. Biol Psychiatry, 43, 908-912
(65) Sander T, Syagailo Y, Samochowiec J, Okladnova O, Lesch KP, Janz D (1999) Association analysis of a regulatory promoter polymorphism of the PAX-6 gene with idiopathic generalized epilepsy. Epilepsy Res, 36, 61-67
(66) Schmidt LG, Sander T, Kuhn S, Smolka M, Rommelspacher H, Samochowiec J, Lesch KP (2000) Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics. J Neural Transm, 107, 681-689
(67) Schulze TG, Müller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV, Windemuth C, Neidt H, Grässle M, Papassotiropoulos A, Heun R, Nöthen MM, Maier W, Lesch KP, Rietschel M (2000) Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder. Am J Med Genetics, 96, 801-803
(68) Sohma H, Hashimoto E, Shirasaka T, Tsunematsu R, Ozawa H, Boissl KW, Böning J, Riederer P & Saito T (1999) Quantitative reduction of type I adenylate cyclase in human alcoholics. Biochemica Biophsysika Acta, 1454, 11-18
(69) Sora I, Hall FS, Andrews A, Liu QR, Itokawa M, Li XF, Wei HB, Wichems C, Lesch KP, Murphy DL, Uhl GR (2001) Molecular mechanism of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine reward. Proc Natl Acad Sci USA, 98, 300-305
(70) Sora I, Wichems C, Takahashi N, Li XF, Donovan D, Rovay R, Zeng Z, Lesch KP, Murphy DL & Uhl GR (1998) Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice. Proc Natl Acad Sci USA, 95, 7699-7704
(71) Spanagel R & Kornhuber J (1999) Glutamatrezeptorantagonisten und Alkoholabhängigkeit. Präklinische Befunde. Nervenarzt, 70, 479?481
(72) Syagailo YV, Stöber G, Grässle M, Reimer E, Jungkunz G, Okladnova O, Meyer J, Lesch KP (2001) Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders. Am J Med Genetics, 105,168-171
(73) Thome J, Baumer A, Harsanyi A, Foley P, Kornhuber J, Wiesbeck GA, Rösler M & Riederer P (1996) The Gly/Glu polymorphism of the neurotrophin 3 gene: Allele frequencies in a caucasian population and relevance for psychiatric disorders. Neuroreport, 7, 1623-1626
(74) Thome J, Foley P, Gsell W, Davids E, Wodarz N, Wiesbeck GA, Böning J, Riederer P (1997) Increased concentrations of manganese superoxide dismutase in serum of alcohol-dependent patients. Alcohol & Alcoholism, 32, 65-69
(75) Thome J, Gerwirtz JC, Weijers H-G, Wiesbeck GA, Henn FA (2000) Genome polymorphism and alcoholism. Pharmacogenomics, 1, 63-71
(76) Thome J, Keinosuke N, Foley P, Gsell W, Wiesbeck GA, Böning J & Riederer P (1997) Time course of manganese superoxide dismutase concentrations in serum of alcohol-dependent patients during abstinence. Drug and Alcohol Dependence, 44, 151-155
(77) Thome J, Weijers H-G, Wiesbeck GA, Sian J, Nara K, Böning J & Riederer P (1999) Dopamine D3 receptor gene polymorphism and alcohol dependence: Relation to psychometric testing. European Archives of Psychiatry and Clinical Science Psychiatric Genetics, 9, 17-21
(78) Thome J, Zhang J, Davids E, Foley P, Weijers H-G, Wiesbeck GA, Böning J, Riederer P & Gerlach M (1997) Evidence for increased oxidative stress in alcohol-dependent patients provided by quantification of in vivo salicylate hydroxylation products. Alcoholism: Clinical and Experimental Research, 21, 82-85
(79) Thome J, Nara K, Foley P, Gsell W, Wiesbeck GA, Böning J & Riederer P (1997) Time course of manganese superoxide dismutase concentrations in serum of alcohol-dependent patients during abstinence. Drug Alc Depend, 44, 151-155
(80) Türker T, Sodmann R, Goebel U, Jatzke S, Knapp M, Lesch KP, Schuster R, Schütz H, Weiler G & Stöber G (1998) High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene. Neurosci Lett, 248, 147-150
(81) Weijers H-G, Wiesbeck GA, Böning J (1999) Temperament-/Charakter-Merkmale und - Merkmalmuster bei alkoholkranken Männern und Kontrollen. Nervenarzt, 70, 998-1008
(82) Weijers H-G, Wiesbeck GA, Böning J (2001) Reflection-impulsivity, personality and performance: a psychometric and validity study on the Matching Familiar Figures Test (MFFT) in detoxified alcoholics. Personality and Individual Differences, 31, 731-754
(83) Weijers H-G, Wiesbeck GA, Jakob F, Böning J (2001) Neuroendocrine response to fenfluramine and its relationship to personality in alcoholism. Journal of Neural Transmission, 108, 1093-1105
(84) Weijers H-G, Wiesbeck GA, Wodarz N, Keller H, Michel T & Böning J (2002) Gender and personality in alcoholism. Archives of Women?s Mental Health (in press)
(85) Wiesbeck GA, Böning J, Weijers H-G, Lesch OM, Glaser T & Toennes PJ (2001) Flupenthixol decanoate in relapse prevention in alcoholics. Results of an European placebo-controlled mulitcenter trial. Alcohol & Alcoholism, 36, 329-334
(86) Wiesbeck GA, Davids E, Wodarz N, Thome J, Jakob F & Böning J (1996) Alcohol withdrawal and dopamine receptor sensitivity after prolonged abstinence. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 20, 1171-1180
(87) Wiesbeck GA, Mauerer C, Thome J, Jakob F & Böning J (1995) Alcohol dependence, familiy history, and D2 dopamine receptor function as neuroendocrinologically assessed with apomorphine. Drug and Alcohol Dependence, 40, 49-53
(88) Wiesbeck GA, Mauerer C, Thome J, Jakob F & Böning J (1995) Neuroendocrine support for a relationsship between ?novelty seeking? and dopaminergic function in alcohol-dependent men. Psychoneuroendocrinology, 20, 755-761
(89) Wiesbeck GA, Mauerer C, Thome J, Jakob F, Boening J (1996) Sensation seeking, alcoholism and dopamine activity. European Psychiatry, 11, 87-92
(90) Wiesbeck GA, Müller T, Wodarz N, Davids E, Kraus T, Thome J, Weijers H-G & Böning J (1998) Growth hormone response to placebo, apomorphine and growth hormone releasing hormone in abstinent alcoholics and control subjects. Drug and Alcohol Dependence, 52, 53-56
(91) Wiesbeck GA, Weijers H-G, Böning J (1999) Untersuchung zur klinischen Gültigkeit der Typ 1/Typ 2 Differenzierung nach Cloninger bei alkoholabhängigen Männern. Suchtmedizin, 1, 27-32
(92) Wiesbeck GA, Weijers H-G, Chick J & Böning J (1999) The effects of ritanserin on mood, sleep, vigilance, clinical impression and social functioning in alcohol-dependent individuals. Alcohol & Alcoholism, 35, 384-389
(93) Wiesbeck GA, Weijers H-G, Chick J, Naranjo CA & Böning J (1999) Ritanserin in relapse prevention in abstinent alcoholics: Results from a placebo-controlled double-blind international multicenter trial. Alcoholism: Clinical and Experimental Research, 23, 230-235
(94) Wiesbeck GA, Weijers H-G, Gross JP (2000) Craving for alcohol and dopamine receptor sensitivity in alcohol-dependent men and control subjects. Journal of Neural Transmission, 107, 691-699
(95) Wiesbeck GA, Weijers H-G, Lesch OM, Glaser T, Tönnes PJ & Böning J (2002) Gender related differences in pharmacological relapse prevention with flupenthixol decanoate. Archives of Women?s Mental Health (in press)
(96) Wodarz N, Wiesbeck GA, Rommelspacher H, Riederer P & Böning J (1996) Excretion of beta-carbolines Harman and Norharman in 24-hour urine of chronic alcoholics during withdrawal and controlled abstinence. Alcohol Clin Exp Res, 20, 706-710
(97) Yamamoto M, Pohli S, Durany N, Ozawa H, Saito T, Boissl KW, Zöchling R, Riederer P, Böning J & Götz ME (2001) Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics. Alcohol & Alcoholism, 36, 70-74
(98) Yamamoto M, Pohli S, Durany N, Ozawa H, Saito T, Boissl KW, Zöchling R, Riederer P, Böning J & Götz ME (2001) Increased levels of calcium-sensitive adenylyl cyclase subtypes in the limbic system of alcoholics: Evidence for a specific role of cAMP signaling in the human addictive brain. Brain Research, 895, 233-237