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Research focus:  

Klinik und Poliklinik für Psychiatrie und Psychotherapie
Füchsleinstr. 15, 97080 Würzburg
Mail: peter.riederer@mail.uni-wuerzburg.de
Url:

Scientific members:

   Professors:

   Scientific assistants:

   Other participating persons and organisations:

Research foci (and basic equipment-based research projects):
Alzheimer’s disease (AD) is the most common cause of dementia in late life. To date, there is no clear-cut consensus whether it involves genetic or environmental factors, or both. Therefore, molecular/biochemical markers for an early detection of AD will provide early means to delay its onset or retard its progress. Oxidative stress (OS) and the involvement of iron have been implicated in the development of several neurodegenerative diseases including AD. The goal of our study is to see whether the enzymes monoamine oxidase B (MAO-B) in platelets, superoxide-dismutase (Cu/Zn-SOD) in erythrocytes and the iron binding protein lactotransferrin (LTF) could be potential markers for the early diagnosis of AD.
In addition we have investigated the possible use of neurotrophic factors as biomarkers in blood, for AD diagnosis. The ciliary neurotrophic factor (CNTF)-null-mutation and the brain derived neurotrophic factor (BDNF)-plasma level were investigated in the Vienna-Transdanube aging (VITA) and the 100-years-project. The first one shows no signs of dementia while the second group has AD.

Results:
(1) Oxidative stress related markers investigated in the Vienna-Transdanube –Aging “VITA” project: The role of platelet monoamine oxidase (MAO-B), erythrocyte superoxide dismutase (SOD) and lactoferrin in Alzheimer’s disease
Riederer P, Schlösser R, Koutsilieri E, Wichart I, Sterba N, Gatterer G, Jellinger KA, Danielczyk W, Fischer P, Tragl KH, Grünblatt E

8th Congress of the Gemran Society for Biological Psychiatry, Düsseldorf, 10-12 October 2002
Psych Clinic Neurosci 252 (1): I/59, 2002
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(2) Neurotrophic factors related markers investigated in the Vienna-Transdanube-Aging “VITA” project: The role of Ciliary-neurotrophic factor (CNTF) nullmutation and Brain-derived neurotrophic factor (BDNF) plasma level in Alzheimer’s disease
Hupp E, Wichart I, Sterba N, Adamcyk W, Dittrich B, Müller F, Oberegger K, Gatterer G, Jellinger KA, Danielczyk W, Fischer P, Tragl KH, Grünblatt E, Riederer P

8th Congress of the Gemran Society for Biological Psychiatry, Düsseldorf, 10-12 October 2002
Psych Clinic Neurosci 252 (1): I/58, 2002
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Differential gene expression in streptozotocin rat model for sporadic Alzheimer’s disease
Grünblatt E, Hoyer S, Riederer P

8th Int. Conference on Alzheimer's Disease and Related Disorders, Stockholm, Sweden, July 20-25, 2002
Neurobiol of Aging 23 (1S):33, 2002
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Sladjana Dukic-Stefanovic, Reinhard Schinzel, Peter Riederer, Gerald Münch (2001) Ages in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs. Biogerontology 2: 19-34
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K.-H. Braunewell, P. Riederer, C. Spilker, E.D. Gundelfinger, B. Borgerts, H.-G. Bernstein (2001) Abnormal Localization of Two Neuronal Calcium Sensor Proteins, Visinin-Like Proteins (VILIPs)-1 and –3, in Neocortical Brain Areas of Alzheimer Disease Patients. Dement Geriatr Cogn Disord 12: 110-116
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P. J. Kahle, M. Neumann, L. Ozmen, V. Müller, S. Odoy, H. Jacobsen, T. Iwatsubo, J. Q. Trojanowski, H. Takahashi, K. Wakabayashi, N. Bogdanovic, P. Riederer, H. A. Kretzschmar, C. Haass (2001) Selective Insolubility of α-Synuclein in Human Lewy Body, Diseases is Recapitulated in an Transgenic Mouse Model; Am. J. Pathol. 159 (6) 2215-2225
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Schnurra I, Bernstein HG, Riederer P, Braunewell KH. (2001) The neuronal calcium sensor protein VILIP-1 is associated with amyloid plaques and extracellular tangles in Alzheimer's disease and promotes cell death and tau phosphorylation in vitro: a link between calcium sensors and Alzheimer's disease?, Neurobiol Dis.8(5):900-9.

Rewards and prizes:
Award of the „Deutsche Gesellschaft für Biologische Psychiatrie“ 8. Kongress DGBP, 10-12 Oktober 2002, Düsseldorf.

Equipment:
CIII position, secretary, laboratory space and equipment for neurochemical/molecularbiological analyses, BATIIa position