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Third-party-funded project

Magnetic resonance study of anatomy, function, and perfusion of the human heart

Project management at the University of Würzburg:

Participating scientists:

Initially, the use of magnetic resonance imaging for the assessment of
cardiac anatomy, function, and perfusion was studied experimentally.
In the years 1999-2001, several MR methods and experimental protocols
were applied to volunteers and patients. Cardiac functional examination
was standardized and used for follow-up studies in patients with aortic
valve stenosis before and after surgical valve replacement as well as in
patients after myocardial infarction and revascularization. Viability
studies were performed by using contrast enhanced MR imaging techniques,
i.e. first-pass perfusion, late enhancement, as well as by analysis of
wall motion during dobutamine stress. Additionally, initial studies or
myocardial perfusion in patients with coronary artery disease were
performed at rest und during adenosine stress. Furthermore, first
experiences were gained with an intravascular contrast agent for the
assessment of myocardial perfusion and regional blood volume. MR coronary
angiography techniques during free breathing and breathholding were
compared with conventional coronary angiography. Current study focus is
the improvement of existing MR techniques concerning temporal and spatial
resolution and the reduction of acquisition time. Real-time and 3D imaging
techniques will be integrated into cardiac examination. Aim of further
study is the development of an integrated cardiac examination protocol
that allows for global examination of the human heart within a reasonable
eximation time.

Projekt period: from 01.1999 to 12.2001