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Third-party-funded project

Title:
Specific function of B-raf in mediating survival of embryonic motoneurons and sensory neurons

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Embryonic sensory and motoneurons depend on neurotrophic factors for survival. Here we show that their survival requires B-Raf, which, in this function, cannot be substituted by C-Raf. Sensory and motoneurons from b-raf-deficient mice do not respond to neurotrophic factors for their survival. However, these primary neurons can be rescued by transfection of a b-raf expression plasmid. In contrast, c-raf-deficient neurons survive in response to neurotrophic factors, similarly to neurons from wild-type mice. This points to an essential and specific function of B-Raf in mediating survival of sensory and motoneurons during development.

Key words:
    Motoneurons
    Sensoric neurons
    Raf
    Apoptosis

Projekt period: from 01.1998 to 12.2001

Funding institution:
DFG ( SFB 465 TP A3 ) ,Granting date: 18.08.1998
Sonstige Stiftung ( Schilling-Stiftung )

Preceding project:
DFG SFB 465

Publications:

Links:
Institute for Clinical Neurobiology