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Third-party-funded project

Title:
Identification of binding proteins for inhibitor of apoptosis proteins

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The inhibitor of apoptosis proteins (IAPs) have been shown to interact with a growing number of intracellular proteins and pathways to fulfil their anti-apoptotic role. In the search for novel IAP-interacting proteins we identified the neurotrophin receptor-interacting MAGE homologue (NRAGE) as being able to bind to the avian IAP homologue ITA. This interaction requires the RING domain of ITA. NRAGE additionally coimmunoprecipitates with XIAP. When overexpressed in 32D cells NRAGE augments interleukin-3 withdrawal induced apoptosis, possibly through binding endogenous XIAP. Moreover, NRAGE is able to overcome the anti-apoptotic effect of Bcl-2.

Key words:
    Apoptosis
    Cell death
    Neurons
    P75
    NRAGE

Projekt period: from 01.1999 to 12.2001

Funding institution:
DFG ( To 61/8-3 u. 8-4 ) ,Granting date: 07.07.1997
Bund ( BMBF Neurotrauma-Verbund )
Sonstige öffentliche Mittel ( Graduiertenkolleg )
Sonstige Stiftung ( A. von Humboldt-Stiftg. )

Preceding project:
SFB 465 TP A4

Publications:

Links:
Institute for Clinical Neurobiology