Association of a Null Mutation in the CNTF Gene with Early Onset of Multiple Sclerosis.
Project management at the University of Würzburg:
Analysis of 800 patients with multiple sclerosis revealed that mutations in the CNTF gene are related with early disease onset and predominant motor symptons in early phases of the disease. The same phenomenon is observed in EAE in mice with inactivation of the CNTF gene. Our results indicate that CNTF acts as a modifier in inflammatory CNS disorder, and that effects of CNTF on oligodendrocyte precursor cell survival and differentiation are an essential component of regenerative processes in inflammatory disorders of the nervous system.
Projekt period: from 01.1999 to 12.2002
DFG to 61/8-4