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Third-party-funded project

Early Onset of Degenerative Changes at Nodes of Ranvier in Motor Axons of CNTF Null (-/-) Mutant Mice

Project management at the University of Würzburg:

Participating scientists:

Inactivation of the CNTF gene leads to progressive degeneration of motoneurons. We have investigated, whether the loss of motoneurons is preceded by axonal changes. In cooperation with Dr. Gatzinsky, University of Uppsala, we could demonstrate that the structure of paranodal networks is changed during early stages of the degenerative process in CNTF-/- mice. These changes indicate that alteration in the signalling between Schwann cells and axons plays a crucial role in the initiation of the disease in CNTF-/- mice.

Key words:
    Motoneuron disease

Projekt period: from 01.2000 to 12.2002

Funding institution:
Sonstige Stiftung ( Schilling-Stiftung ) ,Granting date: 18.08.1998
DFG ( Schwerpunktprogramm "Molekulare Physiologie der Synapsen" )
Wirtschaftsunternehmen ( Ciba Geigy )

Preceding project:
DFG To 61/84


Institute for Clinical Neurobiology