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Third-party-funded project

Title:
SC1, a p75 Neurotrophin Receptor Interacting Protein, is a Transcriptional Repressor and Regulates the Expression of Cell Cycle Specific Genes.

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The SC1 protein has been originally identified as an interaction partner of the cytoplasmic part of the p75 neurotrophin receptor. In order to investigate the function of this protein during development, we have tested the activation of SC1 in various cell lines. We found that SC1 acts as a transcriptional inhibitory for specific genes regulating mitosis. In order to characterize the physiological role of this effect in more detail, we have inactivated the SC1 gene by homologous recombination in mice. SC1 deficient mice die around embryonic day 10. Differentiation of neuronal stem cells will be investigated in more detail in 2003 and 2004.

Key words:
    P75 neurotrophin receptor
    transcriptional inhibition
    mitosis
    neuronal stem cells

Projekt period: from 01.2000 to 12.2004

Funding institution:
Bund ( BMBF Neurotrauma-Verbund ) ,Granting date: 26.09.1994
Sonstige Stiftung ( A. von Humboldt-Stiftung )
Wirtschaftsunternehmen ( Amgen )

Preceding project:
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Publications:

Links:
Institute for Clinical Neurobiology