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Third-party-funded project

COP9 Signalosome Associated Nemo-like Kinase (Nlk) Modulates Neddylation of Cellular Proteins

Project management at the University of Würzburg:

Participating scientists:

Inactivation of the Nlk gene by homologues recombination in mice leads to disturbance of neuronal differentiation, in particular in the cerebellum. In order to characterise this defect in more detail, we have identified interaction partners for Nlk. Nlk associates with components of the signalosome complex. This association leads to changes in neddylation of specific E3 ubiquitin ligases. By this way, various signalling pathways, including the Ras/Raf/MAPK pathway, NFkappaB and wnt cascades are modulated.

Key words:
    Neuronal stem cells

Projekt period: from 01.2000 to 12.2004

Funding institution:
Sonstige Stiftung ( Schilling-Stiftung ) ,Granting date: 18.08.1998
Sonstige Stiftung ( A. von Humboldt-Stiftung )
Landeshaushalt Wissenschaftsministerium

Preceding project:


Institute for Clinical Neurobiology