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Third-party-funded project

Title:
Clopidogrel: Mechanism of action and role as antiplatelet / anti-inflammatory drug

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The central aspect and goal of our project was to enhance the understanding of the physiological / pathophysiological / pharmacological roles of human platelet ADP receptors and the mechanisms of Clopidogrel action. The data obtained in this project, which was supported by Sanofi-Synthelabo and Bristol-Myers Squibb, contributed to the 3-receptor concept of purinergic signaling in human platelets and identified the P2Y12 ADP receptor as molecular target for the antiplatelet drugs ticlopidine and clopidogrel. In several resulting publications, the pharmacology of platelet ADP receptors and their regulation/inhibition by Clopidogrel were described.

Key words:
    Clopidogrel
    Ticlopidine
    Purinergic receptors
    Antiplatelet drugs

Projekt period: from 01.2000 to 06.2002

Funding institution:
Wirtschaftsunternehmen ,Granting date: 21.01.2000

Publications:

Links:
Sanofi-Synthelabo GmbH
Bristol-Myers Squibb GmbH