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Third-party-funded project

Title:
The stress protein alpha-B-crystallin in the cardiovascular system

Project management at the University of Würzburg:

• Dr. Nikola Golenhofen ,Tel: 0931/31 2346,Fax: 0931/31 2712,Mail: nikola.golenhofen@mail.uni-wuerzburg.de
• Prof. Dr. Detlev Drenckhahn ,Tel: 0931/31 2702,Fax: 0931/31 2712,Mail: anat015@mail.uni-wuerzburg.de

Participating scientists:

• Dr. Winfried Ness
• Dr. Athina Hübner ,Tel: 0931/31 2482,Fax: 0931/31 2712,Mail: huebner.athina@mail.uni-wuerzburg.de
• Dr. Rainer Koob ,Tel: 0931/2706,Fax: 0931/31 2712,Mail: rainer.koob@mail.uni-wuerzburg.de

Abstract:
Most cells contain protective proteins (stress proteins, heat shock proteins)
that are able to protect cells from damage and death. An abundant stress
protein of the heart is alpha-B-crystallin. One aspect investigated is the role
of alpha-B-crystallin in myocardial ischemia, studied with knock-out mice.

Key words:
    stress protein
    alpha-B-crystallin
    heart
    ischemia
    cardioprotection

Projekt period: from 01.1999 to 12.2001

Funding institution:
DFG ,Granting date: 02.12.1998

Preceding project:
SFB 355 TP C6 Drenckhahn

Publications:

• Golenhofen N., Htun P., Ness W., Koob R., Schaper W., Drenckhahn D.. (1999). Binding of the stress protein alpha-B-crystallin to cardiac myofibrils correlates with the degree of myocardial damage during ischemia/reperfusion in vivo. J. Mol. Cell Cardiol. 31:569-580, (scientific article)
• Golenhofen N., Drenckhahn D.. (2000). The catenin, p120ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissues. Histochem. Cell Biol. 114:147-155, (scientific article)
• Golenhofen N., Ness W., Wawrousek E.F., Drenckhahn D.. (2002). Expression and induction of the stress protein aB-Crystallin in vascular endothelial cells. Histochem. Cell Biol. 117:203-209, (scientific article)
• Golenhofen N., Arbeiter A., Koob R., Drenckhahn D.. (2002). Ischemia-induced association of the stress protein aB-crystallin with I-band portion of cardiac titin. J. Mol. Cell Cardiol. 34:309-319, (scientific article)
• Redel A., Baumgartner W., Golenhofen K., Drenckhahn D., Golenhofen N.. (2002). Mechanical activity and force-frequency relationship of isolated mouse papillary muscle: effects of extracellular calcium, temperature and contraction type. Pflugers Arch. 445:297-304, (scientific article)

Links:
Anatomy and Cell Biology