Lehrstuhl für physiologische Chemie I
Biozentrum, Am Hubland, 97074 Würzburg
Research foci (and basic equipment-based research projects):
Experimental cancer research, signal transduction, developmental biology, genetics
Molecular genetic and biochemical origins of tumor formation:
Using the well-established model system of melanoma formation in the small laboratory fish Xiphophorus, we are studying the hereditary factors that predispose for tumor development, the functional role of growth factor receptors for the transformation of a normal cell to a cancer cell and the regulation of gene expression in melanoma cells. Another research topic is the instability of the genome in tumor cells as a precondition or consequence of the malignant state of tumors.
The molecular processes and the mechanisms, which determine the development of the male and female sex and the differentiation of the gonads are not well understood today. Also for such research, small laboratory fish are perfectly suited to find the genes, which regulate these processes.
For more detailed information see webpage of "Physiological Chemistry I" on the homepage of the Biocenter, University of Wuerzburg.