Title:
Map refinement towards sequence ready contigs, and structure-function analysis on the short arm of chromosome 11
Project management at the University of Würzburg:
Abstract:
1) The construction of a sequence-ready contig map of human chromosome 11p regions. 2) Biological studies on 11p involving structure-function analysis, gene cloning, studies on involvement of candidate genes in important human diseases such as cancer, mental retardation, overgrowth malformation syndromes or aniridia.
Chromosome 11p has been intensely studied because of its association with adult tumours (amongst others lung, breast, bladder), childhood tumours (Wilms tumour, rhabdomyosarcoma, hepatoblastoma, adrenocortical carcinoma, neuroblastoma) and leukaemia?s. In addition, many human disorders map to this chromosome arm and many genes have been identified. 11p Is also a model chromosome to study parental imprinting. The 11p map generated within this project has provided us further with valuable scientific and clinical information such as information for DNA diagnostics, chromosome structure, imprinting and gene expression. Impressive patient and technology resources were brought together within this project. By using information generated within this project directly for our biological studies the achievements, activities and infrastructure established during the preceding human genome research programs were consolidated and maximally used. The generated integrated map of 11p has enhanced our functional studies. Our improved knowledge about the involvement of genetic factors in human disease, mutagenesis, abnormal development or cancer will enhance human health. All data were stored in a user friendly computer system and made available to others to improve maximum exchange of knowledge about the 11p map.
Key words:
human genome project
Projekt period: from 07.1994 to 06.1999
Funding institution:
EU ( BMH4-CT96-1428 )
Links:
web page
Report 2000