Analysis of signaling molecules following retroviral-mediated expression in haematopoietic cells
Project management at the University of Würzburg:
Our aim is to target different regulators of lymphoid/myeloid developmental programs by mis-expressing members of three different classes of signaling molecules in HSCs. Among these are the transcription factor GABPa/b, the protein kinase HPK1, which is highly expressed in HSCs and the transcriptional co-activator CREB-binding protein CBP/p300.
We analyse the biological role of these regulatory molecules in normal and abnormal lymphoid development by retroviral transduction into HSCs. Transduced
stem cells are analysed in vitro and in vivo following injections into immunc-ompromised recipient mice of different genetic backrounds.
Projekt period: from 11.2000 to 11.2003
DFG ,Granting date: 06.11.2000