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Third-party-funded project

Title:
Importance of endogenously formed 4-hydroxy-2-nonenal for carcinogenicity: Detection of DNA adducts in animals and humans; cancer prevention

Project management at the University of Würzburg:

Participating scientists:

Abstract:
4-Hydroxy-2-nonenal is permanently, endogenously formed by oxidative stress, is genotoxic, mutagenic, forms promutagenic DNA adducts and widely contributes to endogenously induced cancer. Certain pathophysiological processes like inflammation lead to increased lipid peroxidation, enhanced DNA adduct formation and to higher cancer risk. Antioxidative species e.g. secondary components of plants or inhibitors of cyclooxygenases can act protectively. The aim of this research grant is to measure HNE-DNA adduct levels as markers for cancer risk with a limit of detection of 2 adducts/10 9 nucleotides in human and animal tissues and in cell culture systems to investigate the role of pathophysiological processes in increase of cancer risk or, vice versa, to investigate the role of antioxidative compounds and mechanisms in reduction of cancer risk.

Key words:
    HNE-DNA adducts
    Lipid peroxidation
    Cancer
    Chemoprevention

Projekt period: from 12.2002 to 11.2004

Funding institution:
Sonstige Stiftung ( Deutsche Krebshilfe )

Preceding project:
Eder-Deutsche Krebshilfe 10-1645-ED 2 HNE-DNA-Addukte Präventivmaßnahmen