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Third-party-funded project

Title:
Role and Mechanism of Apoptosis in HIV Infection

Project management at the University of Würzburg:

Participating scientists:

Abstract:
The mechanism underlying the T helper cell depletion in HIV infection is still unknown. Our analyses demonstrate that contact of HIV-infected with uninfected CD4+ T lymphocytes result in rapid cell death and cell depletion in vitro. Interactions between the HIV glycoproteins and the receptors on uninfected cells are involved in this process. Apoptotic cell death is observed In cell culture but is not causally related to the cell death. Instead, pre-existing low levels of apoptosis act in a dominant fashion upon fusion of infected with uninfected cells and cause spread of cell death in syncytia.

Key words:
    HIV
    T helper lymphocytes
    glycoprotein
    apoptosis

Projekt period: from 02.1998 to 04.2001

Funding institution:
DFG ,Granting date: 08.12.1997

Publications: