Role and Mechanism of Apoptosis in HIV Infection
Project management at the University of Würzburg:
The mechanism underlying the T helper cell depletion in HIV infection is still unknown. Our analyses demonstrate that contact of HIV-infected with uninfected CD4+ T lymphocytes result in rapid cell death and cell depletion in vitro. Interactions between the HIV glycoproteins and the receptors on uninfected cells are involved in this process. Apoptotic cell death is observed In cell culture but is not causally related to the cell death. Instead, pre-existing low levels of apoptosis act in a dominant fashion upon fusion of infected with uninfected cells and cause spread of cell death in syncytia.
Projekt period: from 02.1998 to 04.2001
DFG ,Granting date: 08.12.1997