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Third-party-funded project

Title:
Immunological Correlates of Protection from HIV Infection and Disease

Project management at the University of Würzburg:

Participating scientists:

Abstract:
HIV disease does not progress in a small subpopulation of HIV-infected individuals despite infection for several years. An important correlate of protection from disease progression is the presence of a particularly vigorous HIV-specific T helper cell immune response. In this study a group of HIV-infected individuals was identified that exhibits strong proliferative responses to the HIV Gag protein. Proliferative responses were detected in both treated and untreated individuals. A negative correlation between proliferative activity and virus load was observed in untreated individuals. Several HIV Gag T helper cell epitopes were characterized.

Key words:
    HIV
    T helper lymphocytes
    immune response

Projekt period: from 06.1998 to 05.2001

Funding institution:
Bund ,Granting date: 24.03.1997
EU

Publications: