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Third-party-funded project

Title:
Identification and characterization of cellular receptors for lymphotropic measles virus strains and investigation of the role of viral envelope proteins for tropism and virulence

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Tropism and virulence of measles virus (MV) are determined largely by the utilization of certain cellular receptors. Also the MV-induced proliferation-inhibition of lymphocytes is a receptor-mediated phenomenon, which depends on the viral envelope proteins. CD46, which was identifyed a a receptor for MV-vaccine strains, does not direktly influence the proliferation inhibition. We succeeded in isolating several monoclonal antibodies inhibiting the infection of cells with wildtype MV-strains. One monoclonal antibody (mAb 5C6) recognizes CD150, a receptor of activated lymphocytes, monocytes, and dendritic cells.Interaction of this surface molecule could contribiute to the virally induced immunosuppression. In addition, there exist good animal models (mice and rats) for the MV-induced central nervous system diseases. We began to clone recombinant viruses to elucidate the molecular determinants of neurovirulence of MV-variants in animal models and tissue culture.

Key words:
    measles virus
    cellular receptor
    CD150
    neurovirulence

Projekt period: from 01.2001 to 12.2001

Funding institution:
DFG ,Granting date: 21.09.2000

Publications: