Molecular basis of measles virus-induced immunosuppression
Project management at the University of Würzburg:
The generalised immunosuppression is the major cause of the high morbidty/mortality rates associated with acute measles. In spite of its clinical relvance, mechanisms underlying MV-induced immunosuppression are far from being understood. Findings available are compatible with MV interference with both viability and function of professional antigen presentign cells such as monocytes and dendritic cells, but also with direct inhbition of lymphocytes. The latter is mirrored by the general failure of lymphocytes isolated from patients to expand in response to polyclonal or antigen-specific stimulation. As revealed by previous investigations, the MV glycoprotein (gp) complex consisting of the H and the proteolytically activated F protein, interacts with an as yet unknown receptor structure on lymphocytes and this leads to a markedly delayed entry of uninfected lymphocytes into the S phase of the cell cycle. Based on these findings, this project aims to characterise 1) the immunosuppressive domains with the F/H complex, 2) the relevant receptor structure, and 3) the MV contact-dependent regulation of intracellular signaling cascades.
Projekt period: from 01.1998 to 12.2003
DFG ( SFB )