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Third-party-funded project

Title:
A Transgenic Mouse Model for the Analysis of Measles Virus-Induced Immune Suppression

Project management at the University of Würzburg:

Participating scientists:

Abstract:
Immune suppression during measles virus infection accounts for most of the morbidity and mortality associated with this disease. However, the mechanisms of MV-induced immune suppression are still unclear; a situation which is largely due to the absence of a suitable animal model. Mice and rats, which are immunologically well defined, generally do not support MV replication and the study of larger animals, for example primates, is hampered by ethical and economic reasons. We have generated a transgenic mouse in which the MV glykoproteins that mediate immune suppression are expressed, in a tissue specific fashion, under the control of an exogenously regulated promoter. This model system will allow us: to study the immunological parameters involved in MV-induced immune suppression, in a well characterised system and to mimic the process of infection and re-infection by inducing and suppressing the activity of the regulatable promoter.

Key words:
    measles
    tet-inducible promoter

Projekt period: from 01.1999 to 12.2001

Funding institution:
Sonstige Stiftung ( Thyssen-Stiftung ) ,Granting date: 26.01.1998

Publications: