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Third-party-funded project

Molecular Mechanisms Controling NFATc1 Transcription in Lymphoid Cells in vivo

Project management at the University of Würzburg:

Participating scientists:


In TPC5 molecular mechanisms shall be determined which control the activity of the Nfatc1 locus in

peripheral T cells in vivo. We intend to investigate (1.) which remote regulatory DNA elements

control the Nfatc1 locus in vivo and (2.) which factors and mechanisms acting through (proximal)

promoter and (remote) enhancer/silencer elements regulate the induction, autoregulation and

repression of NFATc1/αA transcription in peripheral T cells, i.e. of a gene whose expression is under

control of a postive feedback mechanism. These experiments shall elucidate mechanisms controling

decisive steps of immunity or tolerance induction.

Key words:

Projekt period: from 07.2008 to 06.2012

Funding institution: