Analyses of signalling molecules involved in normal and malignant development of haemopoietic stem cells.
Project management at the University of Würzburg:
Many different genetic alterations correlated with different types of human tumours raise questions as to whioch of these changes were essential for the initiation and/or further progression of malignancy. Our long-term goal is to develop an experimental model sysrtem to identify dominantly acting components in human acute myeloid leukaemia (AML) and other malignancies.
In the frame of current we will target different regulators of lymphoid development by mis-expression of three different signalling molecules in murine haemopoietic stem cells (HSCs): a protein kinase highly expresssed in HSCs (HPK-1); a transcription factor (GABPa/b) which competes for the binding with the lympho-myeloid specific factor PU.1, and the hybrid MLL-CBP transcriptional co-activator, associated with secondary, therapy-related acute myeloid leukaemia (t-AML).
Projekt period: from 01.2001 to 12.2003
DFG ( FOR 303-C1 ) ,Granting date: 06.11.2000