NF-AT Transcription Factors as Tumor Suppressors of T Cell Lymphomas
Project management at the University of Würzburg:
NF-AT Transcription Factors play an important role in the activation, differentiation and apoptosis of T lymphocytes. Several observations, such as (1.) the occurrence of a insertion sequence of tumor virus SL3-3 within the promoter of NFATc1, (2.) the silencing of NFATc1 expression after insertion of SL3-3 virus, (3.) the control of NFATc1 expression by DNA methylation, and (4.) the inactivation of NFATc1 expression in Hodgkin and further tumors suggest that NF-AT factors correspond to tumor suppressors for the generation of T cell tumors. The experiments of this project will be done to test this assumption and show by which mechanisms the expression of NF-ATs is inactivated in lymhomas.
Projekt period: from 07.2002 to 07.2004
Sonstige Stiftung ( Deutsche Krebshilfe ) ,Granting date: 01.07.2002