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Third-party-funded project

Title:
NF-AT Target Genes and the Induction of the 'Activation Induced Cell Death' (AICD)

Project management at the University of Würzburg:

• Prof. Dr. Edgar Serfling ,Tel: 201 474 31,Fax: 201 471 31,Mail: serfling.e@mail.uni-wuerzburg.de

Participating scientists:

• PD Dr. rer. nat Manfred Neumann
• Dr. rer. nat. Andris Avots ,Tel: 201 45 851,Fax: 201 45 887,Mail: andy_avots@hotmail.com

Abstract:
Inactivation of the NFATc2 (=NFATp) gene in mice showed that their T cells have defects in the induction of the 'Activation Induced Cell Death' (AICD). Further analyses in our laboratory indicated that also NFATc3 and NFATc1/C, the longest isoform of NFATc1, are able to induce AICD. In the frame of this project we would like to determine by retroviral infections and the creation of 'knock in' mice following by investigations using cDNA microarrays the target genes which control AICD of T lymphocytes.

Key words:
    NF-AT Transcription Factors
    Target Genes
    Apoptosis

Projekt period: from 06.2001 to 05.2003

Funding institution:
Sonstige Stiftung ( Wilhelm-Sander-Stiftung ) ,Granting date: 25.06.2001

Preceding project:
Wilhel-Sander-Stiftung AZ 1999.001.1

Publications:

• Chuvpilo S, Zimmer M. Kerstan A, Glöckner J, Avots A, Escher C, Inashkina I, Jankevics E, Berberich-Siebelt F, Schmitt E and Serfling E. (1999a). Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.. Immunity 10, 261-269, 21. (scientific article)
• Chuvpilo S, Avots A, Berberich-Siebelt F, Glöckner J, Fischer C, Kerstan A, Escher C, Inashkina I, Hlubek F, Jankevics E, Brabletz T and Serfling E. (1999b). Multiple NF-AT isoforms with individual transcriptional properties are synthesized in T lymphocytes.. J.Immunol. 162, 7294-7301, 7. (scientific article)