Title:
On the pharmacology of m-iodobenzylguanidine (MIBG)
Project management at the University of Würzburg:
Abstract:
On the Pharmacology of m-iodobenzylguanidine (MIBG). Despite the widespread use of MIBG in clinical oncology and cardiology, there is paucity of published data on the pharmacology of MIBG. We have previously shown that MIBG has tyramine-like actions in vitro. Therefore, one goal of the present study was to determine how the indirect-sympathomimetic actions of MIBG compare with those of tyramine in vivo. The similarity of the chemical structure of MIBG to that of gunethidine led to the hypothesis that MIBG acts like an adrenergic neurone blocking agent. This working hypothesis has never been verified experimentally. Therefore, another goal of the present study was to determine whether MIBG blocks the nerve stimulation-induced release of noradrenaline and whether MIBG, like many other adrenergic neurone blocking drugs, inhibits monoamine oxidase.
Key words:
m-Iodobenzylguanidine
Projekt period: from 05.1999 to 06.2001
Funding institution:
DFG ( GR 490/10-2 ) ,Granting date: 26.05.1999
Preceding project:
GR 490/10-1
Publications: