Genetic contribution to the pathogenesis of osteoarthritis - Identification of osteoarthritis associated gene products
Project management at the University of Würzburg:
Osteoarthritis is a chronic disease which displays alterations in remodeling of bone, mesenchyme and cartilage. Until now the underlying molecular mechanisms are insufficiently known. The project aims to establish RNA isolation from human cartilage using material from patients with or without osteoarthritis. With RNA pools from cartilage and synovia RT-PCR analyses shall identify known osteoarthritis associated gene products. This characterization should the allow us to perform gene-chip studies to identify novel osteoarthritis associated gene products.
Also the project aims to analyze DNA polymorphisms. For this purpose DNA collections from three different groups are performed. Patients at high age with osteoarthritis, patients with early manifestation of the disease and a control group. Particularly the collection from patients with early disease manifestation should allow to study the relevance of the contribution of genetics to the pathophysiology of the disease.
Projekt period: from 06.2001 to 06.2003
Sonstige Stiftung ( Arbeitsgemeinschaft für Arthrose ) ,Granting date: 25.05.2001