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Third-party-funded project

Elucidation of the function and relevance of hCYR61 in human bone cells

Project management at the University of Würzburg:

Participating scientists:

The human gene encoding cystein rich protein 61 and the human thioredoxin reductase were identified by differential display PCR from human osteoblasts. hCYR61 belongs to a family (CCN-family) with importance for signaling of the extracellular matrix. Thioredoxin reductase is a regulator of the redox-state of cells. No data for human bone cells are available as yet. The exon-intron structure for the hCYR61 gene shall be elucidated and the promoter should be cloned. The expression of the mRNA and the protein for hCYR61 and thioredoxin reductase shall be studied in human osteoblasts. Results of the project should contribute to a better understanding of protein function in the bone micrenvironment.

Key words:
    cysteine rich protein 61
    CCN family
    thioredoxin reductase

Projekt period: from 11.1998 to 11.2000

Funding institution:
DFG ( JA 504/4-1 ) ,Granting date: 15.06.1998