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Third-party-funded project

Elucidation of the function and relevance of hCYR61 in human bone cells

Project management at the University of Würzburg:

Participating scientists:

The human cystein rich protein 61 (hCYR61) is expressed in mesenchymal cells and osteoblasts in human bone and regulated by bone-relevant factors at the mRNA and protein level. hCYR61 is processed via the Golgi apparatus and is subsequently secreted. The gene product functions in human bone as a signaling molecule. Aim of the study is the further elucidation of the regulation and function of hCYR61 in human bone cells and the contribution to the pathogenesis of bone diseases such as osteoporosis. Polymorphisms in the gene region have been detected by our group and shall be analyzed with respect to bone density. The expression and regulation of the hCYR61 mRNA and protein shall be analyzed in mesenchymal stem cells from human bone marrow. Expression of the recombinant protein is aimed to analyze hCYR61 functions in bone cells, to define target cells in bone metabolism and to analyze hCYR61 dependent signal transduction. Results of the project should contribute to a better understanding of the hCYR61 function in bone and the importance in bone diseases.

Key words:
    Cysteine rich protein 61

Projekt period: from 11.2000 to 11.2002

Funding institution:
DFG ( Schu 747/4-3 ) ,Granting date: 16.10.2000

Preceding project:
DFG JA 504 4-1