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Third-party-funded project

Relevance of proteins of the CCN family in mesenchymal stem cells and application of hCYR61 in Bone and cartilage replacement.

Project management at the University of Würzburg:

hCYR61 is a extracellular matrix associated signalling gene product, which belongs to a new family of cystein rich proteins, the CCN family. We characterized hCYR61 as a immediate early gene in osteoblasts, which is regulated by vitamin D3, cytokines and growth factors. In previous work we found enhanced expression of hCYR61 in endochondral ossification and in fracture repair. According to the important role of hCYR61 in development and remodeling of bone we will characterize the putative role of rhCYR61 and other members of the family in tissue engineering with respect to vascularization and organification of "ossikels", which are grown on preformed matricesin vitro. We will primarily use mesenchymal stem cells and examine the function of CCN-proteins along differentiation into bone relevant cell types by studying differential gene expression after overexpression and cellular knockout. Our aim is to establish procedures for tissue replacement involving hCYR61 protein. Given that positive effects occur the methods apply shall be patented.

Key words:
    bone and cartilage replacement
    osteogenic differentiation

Projekt period: from 01.2002 to 12.2004

Funding institution:
DFG ( Klinische Forschergruppe ) ,Granting date: 30.11.2001
Sonstige öffentliche Mittel ( Bezirk Unterfranken )