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Third-party-funded project

Title:
Influence of size of different ceramic and titanium particles in particle disease - a macrophages culture study

Project management at the University of Würzburg:

• PD Dr med Christof P Rader

Participating scientists:

• Dr med Bernd Baumann
• Dr med Olaf Rolf
• PD Dr rer nat Norbert Schütze
• Dr med Thomas Sterner

Abstract:
In this project the influence of particle size of different particle materials in a macrophage modell (differentiated THP-1 cells) is analysed. Particularly, Al2O3 particles result in a reduced sekretion of the osteoresorptive cytokine TNF alpha, compared to metal particles. Due to the known low level of waer debris resulting from ceramic implants, these materials can be recommended for endoprothetic procedures.

Key words:
    particle disease
    macrophage cell culture

Projekt period: from 01.1999 to 01.2003

Publications:

• O Rolf, CP Rader, T Sterner, U Nöth, Jakob, N Schütze, J Eulert. (2001). Charakterisierung und in-vitro Versuche von Metallosepartikel im Makrophagenmodell. Biomedizinische Technik (Zur Begutachtung), (scientific article)
• O Rolf, CP Rader, J Eulert. (1998). Charakterisierung von Metallosepartikel nach Hüft-/Knie-TEP und ihre Testung in einer Makrophagenzellkultur. In Zeitschrift für Orthopädie 136:A151 . (conference publication)